Lipid-coated polyplexes for targeted gene delivery to ovarian carcinoma cells
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چکیده
منابع مشابه
SRL-coated PAMAM dendrimer nano-carrier for targeted gene delivery to the glioma cells and competitive inhibition by lactoferrin
Glioma, as a primary tumor of central nervous system, is the main cause of death in patients with brain cancer. Therefore, development of an efficient strategy for treatment of glioma is worthy. The aim of the current study was to develop a SRL peptide-coated dendrimer as a novel dual gene delivery system for targeting the LRP receptor, an up-regulated gene in both BBB and glioma cells. To perf...
متن کاملSRL-coated PAMAM dendrimer nano-carrier for targeted gene delivery to the glioma cells and competitive inhibition by lactoferrin
Glioma, as a primary tumor of central nervous system, is the main cause of death in patients with brain cancer. Therefore, development of an efficient strategy for treatment of glioma is worthy. The aim of the current study was to develop a SRL peptide-coated dendrimer as a novel dual gene delivery system for targeting the LRP receptor, an up-regulated gene in both BBB and glioma cells. To perf...
متن کاملCationic lipid-coated PEI/DNA polyplexes with improved efficiency and reduced cytotoxicity for gene delivery into mesenchymal stem cells
BACKGROUND Effective gene transfection without serum deprivation is a prerequisite for successful stem cell-based gene therapy. Polyethylenimine (PEI) is an efficient nonviral gene vector, but its application has been hindered by serum sensitivity and severe cytotoxicity. METHODS To solve this problem, a new family of lipopolyplexes was developed by coating PEI/DNA polyplexes with three serum...
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Gene therapy is believed to be the therapy of the future because it aims to eradicate causes rather than symptoms of diseases. The generic aim of gene therapy is to deliver DNA inside cells in order to achieve a stable and regulated expression of transgenes in the target cells or tissues without side effects. Spontaneous entry of naked DNA inside cells is an inefficient process, consequently, a...
متن کاملLipid-Coated Nanoscale Coordination Polymers for Targeted Delivery of Antifolates to Cancer Cells.
Nanoscale coordination polymers (NCPs) have been demonstrated as an interesting platform for drug delivery, as they possess many advantages over small-molecule chemotherapeutics, such as high payloads, lower systemic toxicity, tunability, and enhanced tumor uptake. Existing formulations for the delivery of methotrexate (MTX), an antifolate cancer drug, have very low drug loadings. Herein, we re...
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ژورنال
عنوان ژورنال: Cancer Gene Therapy
سال: 2001
ISSN: 0929-1903,1476-5500
DOI: 10.1038/sj.cgt.7700311